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What Does Dipeptide-6 Do in Cosmetics?
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Product Description
1. MOA - Mechanism of Action
Dipeptide-6, also known as Alanyl-Glutamine, is a stabilized and highly bioavailable precursor to the amino acid L-Glutamine. Its primary mechanism of action is centered on cellular energy metabolism and hydration:
Precursor to L-Glutamine: Upon topical application, Dipeptide-6 is efficiently cleaved by skin enzymes (peptidases) to release its constituent amino acids, L-Alanine and the critically important L-Glutamine.
Fuel for Proliferating Cells: L-Glutamine is a primary energy source for rapidly dividing cells, including fibroblasts (which produce collagen, elastin, and hyaluronic acid) and keratinocytes. It supports cellular biosynthesis and regeneration.
Osmolyte Function & Aquaporin Activation: L-Glutamine serves as an osmolyte, helping to regulate cellular volume. It has been shown to influence the expression and function of Aquaporin-3 (AQP3), a channel protein responsible for transporting water and glycerol into skin cells.
Antioxidant Support: L-Glutamine is a precursor to glutathione, one of the body's most powerful endogenous antioxidants, helping to protect skin cells from oxidative stress.
In summary: Dipeptide-6 → Delivers L-Glutamine → Fuels Cellular Energy → Enhances AQP3-mediated Hydration → Supports Skin Repair & Antioxidant Defense.
2. In Vitro Efficacy Data
Fibroblast Energy Metabolism: In vitro studies on human dermal fibroblasts demonstrate that treatment with Dipeptide-6 increases intracellular ATP levels, indicating enhanced cellular energy and metabolic activity.
Aquaporin-3 Up-regulation: Tests on skin equivalent models show that Dipeptide-6 significantly up-regulates the expression of the Aquaporin-3 channel.
Hydration & Barrier Function: In vitro measurements on reconstituted human epidermis models confirm a marked increase in skin hydration and an improvement in barrier function following treatment with Dipeptide-6.
3. Clinical Results
Study: Anti-Wrinkle and Hydrating Efficacy
a. Design: Clinical study on female volunteers with signs of skin aging and dryness.
b. Formula: A cream containing 2% Dipeptide-6 applied twice daily for 56 days.
c. Results (Instrumental & Clinical Evaluation):
*Reduction of Wrinkle Depth & Volume: Instrumental analysis (e.g., skin replicas) showed a significant reduction in the depth and volume of fine lines and wrinkles after 28 and 56 days.
*Boost in Skin Hydration: Corneometry measurements indicated a dramatic increase (over 30%) in skin hydration levels.
*Improvement in Skin Elasticity & Firmness: Cutometry assessments confirmed a statistically significant improvement in skin elasticity and firmness.
*Clinical Grading: Expert visual grading noted a visible improvement in skin smoothness, plumpness, and overall radiance.
Safety Profile
Dipeptide-6 is composed of two natural, skin-identical amino acids. It is exceptionally safe and well-tolerated.
Skin Irritation Test: Proven to be non-irritating and non-sensitizing, suitable for all skin types, including sensitive skin.
Biocompatibility: As a natural peptide derivative, it exhibits excellent biocompatibility with skin biology.
Skin Irritation Test: Proven to be non-irritating and non-sensitizing, suitable for all skin types, including sensitive skin.
Biocompatibility: As a natural peptide derivative, it exhibits excellent biocompatibility with skin biology.
Compatibility & Formulation Guidelines
Solubility: Highly soluble in water.
PH Stability: Stable in a broad pH range (typically 4.0 - 8.0). As with all peptides, stability in the final formulation should be verified.
Temperature: Incorporate at temperatures below 45°C to maintain stability.
Compatibility: Compatible with a wide range of cosmetic ingredients, including other humectants, emollients, and active compounds. It is an excellent candidate for synergistic formulations with other anti-aging ingredients.
PH Stability: Stable in a broad pH range (typically 4.0 - 8.0). As with all peptides, stability in the final formulation should be verified.
Temperature: Incorporate at temperatures below 45°C to maintain stability.
Compatibility: Compatible with a wide range of cosmetic ingredients, including other humectants, emollients, and active compounds. It is an excellent candidate for synergistic formulations with other anti-aging ingredients.
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Recommended Dosage & Formulation
Recommended Concentration: 1.0% - 5.0% in the final product.
Ideal Product Forms:
Anti-aging Serums and Ampoules
Moisturizing Creams and Lotions
Hydrating & Plumping Sheet Masks
Eye Creams (for hydration and fine lines)
Barrier Repair Formulations
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Cellular Energy Booster
Directly fuels skin cells (fibroblasts) to enhance regeneration and repair processes.
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Deep Hydration Technology
Uniquely up-regulates Aquaporin-3 (AQP3) to drive water and glycerol into cells, plumping the skin from within.
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Clinically Proven Anti-Aging
Significantly reduces the appearance of wrinkles and improves skin elasticity and firmness.
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Powerful Hydrator
Provides immediate and long-lasting hydration, improving skin barrier function.
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Safe & Skin-Identical
Composed of natural amino acids, offering an exceptionally high safety profile.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available